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Zoloft

Zoloft is a prescription medicine used in the treatment of depression

Sertraline HCl is a selective serotonin reuptake inhibitor (SSRI) for oral administration. It is chemically unrelated to other SSRIs, tricyclic, tetracyclic, or other available antidepressant agents. It has a molecular weight of 342.7. Sertraline hydrochloride has the following chemical name: (1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-nanphthalenamine hydrochloride. The empirical formula is C₁₇H₁₇NCl₂·HCl.

Sertraline hydrochloride is a white crystalline powder that is slightly soluble in water and isopropyl alcohol, and sparingly soluble in ethanol.

Zoloft is supplied for oral administration as scored tablets containing sertraline hydrochloride equivalent to 25, 50 and 100 mg and the following inactive ingredients: dibasic calcium phosphate dihydrate, Dy & C Yellow #10 aluminum lake (in 25 mg tablet), FD & C Blue #1 aluminum lake (in 25 mg tablet), FD & C Red #40 aluminum lake (in 25 mg tablet), FD&C Blue #2 aluminum lake (in 50 mg tablet), hydroxypropyl cellulose, hydroxypropyl methylcellulose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, sodium starch glycolate, synthetic yellow iron oxide (in 100 mg tablet), and titanium dioxide.

HOW SUPPLIED

Zoloft Tablets

Zoloft capsular-shaped scored tablets containing sertraline hydrochloride equivalent to 25, 50 and 100 mg of sertraline.

25 mg Tablets: Light green film coated tablets engraved on one side with Zoloft and on the back scored and engraved with 25 mg.

50 mg Tablets: Light blue film coated tablets engraved on the front with Zoloft and on the back scored and engraved with 50 mg.

100 mg Tablets: Light yellow film coated tablets engraved on the front with Zoloft and on the back scored and engraved with 100 mg.

Storage: Store at controlled room temperature of 59° to 86°F (15° to 30°C).

ZOLOFT is a prescription medicine used to treat depression, panic disorder, obsessive-compulsive disorder (also called OCD) and posttraumatic stress disorder (also called PTSD) in adults. ZOLOFT is also used to treat OCD in children (ages 6-12) and adolescents (ages 12-17).

Depression

Symptoms of depression vary from person to person. You may have depression if you have five or more of the following symptoms and you have these symptoms almost all of the time during the same two-week period or longer. At least one of the symptoms must be a “sad” feeling that will not go away or a loss of interest or pleasure in most activities. Other symptoms are:

• changes in sleeping patterns
• restlessness or slowed movements
• fatigue or lack of energy
• changes in appetite or weight
• feeling worthless or guilty for no real reason
• trouble concentrating or making decisions

In depression, these symptoms interfere with your day-to-day activities.

Panic Disorder

People with panic disorder have repeated, unexpected panic attacks. A panic attack is an unexpected attack of fear, anxiety or discomfort with at least four or more of the following symptoms that develop suddenly and usually reach a peak within 10 minutes:

• fast heart rate or pounding heart
• chest pain or discomfort
• sweating
• trembling or shaking
• shortness of breath or a feeling of smothering
• choking feeling
• nausea or upset stomach
• dizziness or feeling faint
• numbness or tingling
• chills or hot flashes
• feeling out of touch with reality
• fear of losing control
• fear of dying

In panic disorder, the panic attack(s) are followed by one month or longer of concern about having more attacks, or concern about what effect the panic attack(s) may have, or having a change in behavior.

Obsessive-Compulsive Disorder (OCD)
In OCD, a person may have two types of symptoms called obsessions or compulsions.

Obsessions:

These are unwanted thoughts that stay in a person’s mind. Even though the person knows these thoughts do not make sense, they cannot get rid of them. These thoughts can be frightening and embarrassing.

Compulsions: These are actions or thoughts that a person does over and over again to get rid of their unwanted thoughts. They believe this will help prevent something terrible from happening. These repeated actions may take hours to perform and can interfere with daily life.

Posttraumatic Stress Disorder (PTSD)

People with PTSD suffer from symptoms because they suffered, witnessed or learned of a life-threatening event or other serious event and felt intense fear, helplessness or horror because of the event.

A person with PTSD must have one or more symptoms from each of the following categories for at least a month and these symptoms must seriously interfere with being able to lead a normal life.

• Reliving the event through upsetting thoughts, nightmares or flashbacks, or having very strong mental and physical reactions if something reminds the person of the event.
• Avoiding activities, thoughts, feelings or conversations that remind the person of the event; feeling numb to one’s surroundings; or being unable to remember details of the event. Having a loss of interest in important activities, feeling all alone, being unable to have normal emotions or feeling that there is nothing to look forward to in the future may also be experienced.
• Feeling that one can never relax and must be on guard all the time to protect oneself, trouble sleeping, feeling irritable, overreacting when startled, angry outbursts or trouble concentrating.

ZOLOFT is approved to treat PTSD in both men and women. More women than men experience PTSD. There were three times more women than men in ZOLOFT PTSD clinical studies, and in these studies women responded better to ZOLOFT than men. What this means to the treatment of a patient is unknown. Only a doctor can determine if ZOLOFT is right for a patient.