  Bupropion HCL - Wellbutrin
Bupropion HCL (Wellbutrin) is a prescription drug used to treat depression
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Bupropion HCL (Wellbutrin) Information
Bupropion HCl, an antidepressant of the aminoketone class and a non-nicotine aid to smoking cessation, is chemically unrelated to tricyclic, tetracyclic, selective serotonin re-uptake inhibitor, or other known antidepressant agents. Its structure closely resembles that of diethylpropion; it is related to phenylethylamines. It is designated as (±)-1-(3-chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone hydrochloride. The molecular weight is 276.2. The empirical formula is C13H18ClNO·HCl. Bupropion HCl powder is white, crystalline, and
highly soluble in water. It has a bitter taste and produces the sensation of local anesthesia on the oral mucosa.
Immediate Release Tablets: Wellbutrin is supplied for oral administration as 75 mg (yellow-gold) and 100 mg (red) film-coated tablets. Each tablet contains the labeled amount of bupropion HCl and the inactive ingredients: 75 mg tablet: D&C yellow no. 10 lake, FD&C yellow no. 6 lake, hydroxypropyl cellulose, hydroxypropyl methylcellulose, microcrystalline cellulose, polyethylene glycol, talc, and titanium dioxide; 100 mg
tablet: FD&C red no. 40 lake, FD&C yellow no. 6 lake, hydroxypropyl cellulose, hydroxypropyl methylcellulose, microcrystalline cellulose, polyethylene glycol, talc, and titanium dioxide.
Bupropion HCL (Wellbutrin) Contraindications
Bupropion HCl is contraindicated in patients with a seizure disorder.
Buproprion HCl is contraindicated in patients treated with other medications that contain bupropion because the incidence of seizure is dose-dependent.
Bupropion HCl is also contraindicated in patients with a current or prior diagnosis of bulimia or anorexia nervosa because of a higher incidence of seizures noted in such patients treated for bulimia with bupropion HCl immediate-relase formulation.
The concurrent administration of bupropion HCl and a monoamine
oxidase (MAO) inhibitor is contraindicated. At least 14 days should elapse between discontinuation of an MAO inhibitor and initiation of treatment with bupropion HCl.
Bupropion HCl is contraindicated in patients who have shown an allergic response to bupropion or the other ingredients that make up bupropion HCl.
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